Brian S J Blagg Selected Research

Protein Isoforms (Isoforms)

1/2024	Anti-inflammatory activities of novel heat shock protein 90 isoform selective inhibitors in BV-2 microglial cells.
10/2023	Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
1/2022	Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors.
11/2021	The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
10/2021	Structure-Based Design, Synthesis, and Biological Evaluation of Hsp90β-Selective Inhibitors.
1/2019	The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain.
1/2018	Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor.
12/2017	Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.
1/2017	Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.
4/2016	Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.

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Brian S J Blagg Research Topics

Disease

71	Neoplasms (Cancer) 12/2023 - 06/2004
18	Breast Neoplasms (Breast Cancer) 01/2022 - 11/2004
12	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 04/2007
11	Peripheral Nervous System Diseases (PNS Diseases) 01/2021 - 08/2010
7	Prostatic Neoplasms (Prostate Cancer) 01/2023 - 09/2005
6	Neoplasm Metastasis (Metastasis) 01/2023 - 06/2007
6	Glaucoma 11/2022 - 11/2012
4	Inflammation (Inflammations) 01/2024 - 01/2021
4	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 04/2007
3	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/2018 - 12/2014
3	Multiple Myeloma 10/2017 - 08/2014
2	Tauopathies 01/2023 - 01/2017
2	Virus Diseases (Viral Diseases) 11/2022 - 03/2021
2	Pain (Aches) 01/2020 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2019 - 04/2012
2	Hyperglycemia 01/2019 - 04/2012
2	Demyelinating Diseases (Demyelinating Disease) 01/2018 - 12/2012
2	Type 2 Diabetes Mellitus (MODY) 02/2014 - 01/2012
1	Triple Negative Breast Neoplasms 12/2023
1	Neuroblastoma 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2021
1	Ischemia 12/2021
1	Skin Neoplasms (Skin Cancer) 01/2021
1	Disease Progression 01/2021
1	Melanoma (Melanoma, Malignant) 01/2021
1	follicular Thyroid cancer 01/2021
1	Thyroid Neoplasms (Thyroid Cancer) 01/2021
1	Tuberculosis (Tuberculoses) 12/2020
1	Adrenocortical Carcinoma 01/2020
1	Oncogene Addiction 01/2020
1	Tics (Tic) 01/2020
1	Obesity 01/2019

Drug/Important Bio-Agent (IBA)

46	Proteins (Proteins, Gene)FDA Link 12/2023 - 11/2004
31	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2022 - 09/2006
21	Novobiocin (Streptonivicin)FDA Link 01/2021 - 09/2005
18	Molecular Chaperones (Chaperone, Molecular)IBA 01/2023 - 09/2006
13	glucose-regulated proteinsIBA 11/2022 - 11/2012
12	Protein Isoforms (Isoforms)IBA 01/2024 - 02/2015
9	NAD (NADH)IBA 01/2021 - 08/2010
5	HSP90 Heat-Shock Proteins (Heat-Shock Proteins, HSP90)IBA 11/2021 - 06/2004
5	trabecular meshwork-induced glucocorticoid response proteinIBA 01/2018 - 11/2012
4	Adenosine Triphosphate (ATP)IBA 05/2023 - 09/2010
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 06/2004
4	tanespimycin (17AAG)IBA 01/2020 - 01/2006
4	KU-596IBA 01/2019 - 08/2014
4	AmidesIBA 10/2016 - 06/2009
4	LuciferasesIBA 07/2015 - 10/2011
3	Antineoplastic Agents (Antineoplastics)IBA 05/2023 - 06/2006
3	Superoxides (Superoxide)IBA 01/2023 - 04/2012
3	Peptides (Polypeptides)IBA 01/2022 - 02/2009
3	Oncogene Proteins (Oncogene Protein)IBA 06/2021 - 10/2013
3	benzamideIBA 01/2017 - 03/2008
3	geldanamycinIBA 06/2009 - 01/2006
2	cruentaren AIBA 01/2022 - 12/2012
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021 - 01/2018
2	EnzymesIBA 01/2021 - 01/2018
2	Opioid Analgesics (Opioids)IBA 01/2020 - 01/2019
2	Morphine (MS Contin)FDA LinkGeneric 01/2020 - 01/2019
2	olfactomedinIBA 01/2018 - 12/2014
2	SugarsIBA 10/2016 - 12/2011
2	Neuroprotective AgentsIBA 08/2016 - 08/2014
2	AndrogensIBA 07/2015 - 10/2011
2	geduninIBA 03/2013 - 10/2008
2	Adenosine Triphosphatases (ATPase)IBA 12/2012 - 11/2004
2	PlatinumIBA 07/2012 - 01/2008
2	Insulin (Novolin)FDA Link 03/2012 - 01/2012
2	novioseIBA 12/2011 - 07/2010
2	Protein AggregatesIBA 02/2009 - 04/2007
2	tau Proteins (tau Protein)IBA 02/2009 - 04/2007
2	coumarinIBA 03/2008 - 10/2006
2	monorden (radicicol)IBA 05/2006 - 01/2006
1	LipopolysaccharidesIBA 01/2024
1	enniatinsIBA 12/2023
1	Alkenes (Olefins)IBA 05/2023
1	ChromatinIBA 01/2023
1	InterferonsIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	CurcuminIBA 01/2021
1	HarmalineIBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021
1	methyl tert-butyl ether (MTBE)IBA 01/2021
1	PromegaIBA 01/2021
1	DNA Polymerase thetaIBA 01/2021
1	VemurafenibIBA 01/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	cobimetinibIBA 01/2021
1	vanillinIBA 01/2021
1	lenvatinibIBA 01/2021
1	bedaquiline (R207910)IBA 12/2020
1	DNA GyraseIBA 08/2020
1	benzothiazoleIBA 08/2020
1	Long Noncoding RNAIBA 01/2020
1	TOR Serine-Threonine KinasesIBA 01/2020
1	CateninsIBA 01/2020
1	Aldehyde DehydrogenaseIBA 01/2020

Therapy/Procedure

12	Therapeutics 05/2023 - 05/2012
3	Immunotherapy 01/2023 - 01/2021
3	Drug Therapy (Chemotherapy) 01/2021 - 04/2015